Total synthesis of monosporascone and dihydromonosporascone.
نویسندگان
چکیده
The first total synthesis of monosporascone is presented. The five-step synthesis developed includes a silver acetylide-acid chloride coupling, domino Diels-Alder-retro-Diels-Alder reaction, and an intramolecular Friedel-Crafts acylation, and provides the natural product in 57% yield overall. Selective reduction of monosporascone also afforded the related metabolite dihydromonosporascone.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 12 17 شماره
صفحات -
تاریخ انتشار 2014